2025
Seetharam D, Chandar J, Ramsoomair CK, Desgraves JF, Alvarado Medina A, Hudson AJ, Amidei A, Castro JR, Govindarajan V, Wang S, Zhang Y, Sonabend AM, Mendez Valdez MJ, Maric D, Govindarajan V, Rivas SR, Lu VM, Tiwari R, Sharifi N, Thomas E, Alexander M, DeMarino C, Johnson K, De La Fuente MI, Alshiekh Nasany R, Noviello TMR, Ivan ME, Komotar RJ, Iavarone A, Nath A, Heiss J, Ceccarelli M, Chiappinelli KB, Figueroa ME, Bayik D, Shah AH. Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models. J Clin Invest. 2025 Mar 17;135(6):e183745. doi: 10.1172/JCI183745. PMID: 40091830.
Ishak CA, Marhon SA, Tchrakian N, Hodgson A, Loo Yau H, Gonzaga IM, Peralta M, Lungu IM, Gomez S, Liang SB, Shen SY, Chen R, Chen J, Chatterjee B, Wanniarachchi KN, Lee J, Zehrbach N, Hosseini A, Mehdipour P, Sun S, Solovyov A, Ettayebi I, Francis KE, He A, Wu T, Feng S, da Silva Medina T, Campos de Almeida F, Bayani J, Li J, MacDonald S, Wang Y, Garcia SS, Arthofer E, Diab N, Srivastava A, Austin PT, Sabatini PJB, Greenbaum BD, O'Brien CA, Shepherd TG, Tsao MS, Chiappinelli KB, Oza AM, Clarke BA, Rottapel R, Lheureux S, De Carvalho DD. Chronic viral mimicry induction following p53 loss promotes immune evasion. Cancer Discov. 2025 Apr 2;15(4):793-817. doi: 10.1158/2159-8290.CD-24-0094. PMID: 39776167.
2024
Brodeur MN, Dopeso H, Zhu Y, Longhini ALF, Gazzo A, Sun S, Koche RP, Qu R, Rosenberg L, Hamard PJ, Bykov Y, Green H, Gusain L, Chiappinelli KB, Ozsoy MA, Chui MH, Basili T, Gardner R, Walderich S, DeStanchina E, Greenbaum B, Gönen M, Vabret N, Weigelt B, Zamarin D. Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity. Sci Adv. 2024 Dec 6;10(49):eadk4851. doi: 10.1126/sciadv.adk4851. PMID: 39630912.
Grundy EE, Shaw LC, Wang L, Lee AV, Argueta JC, Powell DJ Jr, Ostrowski M, Jones RB, Cruz CRY, Gordish-Dressman H, Chappell NP, Bollard CM, Chiappinelli KB. A T cell receptor specific for an HLA-A*03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitope. Mob DNA. 2024 Oct 9;15(1):19. doi: 10.1186/s13100-024-00333-w. PMID: 39385229.
Noonepalle SKR, Gracia-Hernandez M, Aghdam N, Berrigan M, Coulibaly H, Li X, Zevallos-Delgado C, Pletcher A, Weselman B, Palmer E, Knox T, Sotomayor E, Chiappinelli KB, Wardrop D, Horvath A, Shook BA, Lee N, Dritschilo A, Fernandes R, Musunuri K, Shibata M, Villagra A. A Cell therapy using ex vivo reprogrammed macrophages enhances antitumor immune responses in melanoma. J Exp Clin Cancer Res. 2024 Sep 14;43(1):263. doi: 10.1186/s13046-024-03182-w. PMID: 39272209.
Lee AV*, Nestler KA*, Chiappinelli KB. Therapeutic Targeting of DNA Methylation Alterations in Cancer. Pharmacol Ther. 2024 Jun;258:108640. doi: 10.1016/j.pharmthera.2024.108640. PMID: 38570075.
Chiappinelli KB. Targeting the DHX9 RNA Helicase to Induce Antitumor Immunity in Small-Cell Lung Cancer. Cancer Discov. 2024 Mar 1;14(3):389-391. doi: 10.1158/2159-8290.CD-23-1523. PMID: 38426559.
2023
Walker RR, Chiappinelli KB. Protein Exaptation by Endogenous Retroviral Elements Shapes Tumor Cell Senescence and Downstream Immune Signaling. Cancer Res. 2023 Aug 15;83(16):2640-2642. doi: 10.1158/0008-5472.CAN-23-1862. PMID: 37549230.
Sweeney EE, Sekhri P, Telaraja D, Chen J, Chin SJ, Chiappinelli KB, Sanchez CE, Bollard CM, Cruz CRY, Fernandes R. A Engineered tumor-specific T cells using immunostimulatory photothermal nanoparticles . Cytotherapy. 2023 Jul;25(7):718-727. doi: 10.1016/j.jcyt.2023.03.014. PMID: 37278683.
Kanholm T, Rentia U, Hadley M, Karlow JA, Cox OL, Diab N, Bendall ML, Dawson T, McDonald JI, Xie W, Crandall KA, Burns KH, Baylin SB, Easwaran H, Chiappinelli KB. Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci. Cancer Res. 2023 Aug 1;83(15):2584-2599. doi: 10.1158/0008-5472.CAN-22-3485. PMID: 37249603.
Kim DJ, Anandh S, Null JL, Przanowski P, Bhatnagar S, Kumar P, Shelton SE, Grundy EE, Chiappinelli KB, Kamm RD, Barbie DA, Dudley AC. Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors. Nat Commun. 2023 Apr 14;14(1):2122. doi: 10.1038/s41467-023-37807-z. PMID: 37055433; PMCID: PMC10101959.
Walker RR, Rentia Z, Chiappinelli KB. Epigenetically programmed resistance to chemo- and immuno-therapies. Adv Cancer Res. 2023;158:41-71. doi: 10.1016/bs.acr.2022.12.001. Epub 2023 Jan 27. PMID: 36990538.
2022
Gomez S, Cox OL, Walker RR 3rd, Rentia U, Hadley M, Arthofer E, Diab N, Grundy EE, Kanholm T, McDonald JI, Kobyra J, Palmer E, Noonepalle S, Villagra A, Leitenberg D, Bollard CM, Saunthararajah Y, Chiappinelli KB. Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer. J Immunother Cancer. 2022 Nov;10(11):e004974. doi: 10.1136/jitc-2022-004974. PMID: 36343976; PMCID: PMC9644370.
Macedo AB, Levinger C, Nguyen BN, Richard J, Gupta M, Cruz CRY, Finzi A, Chiappinelli KB, Crandall KA, Bosque A. The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation. J Virol. 2022 Aug 10;96(15):e0037222. doi: 10.1128/jvi.00372-22. PMID: 35867565.
Chiappinelli KB, Baylin SB. Inhibiting DNA methylation improves antitumor immunity in ovarian cancer. J Clin Invest. 2022 Jul 15;132(14):e160186. doi: 10.1172/JCI160186. PMID: 35838045; PMCID: PMC9282922.
2021
Noonepalle SKR, Karabon L, Chiappinelli KB, Villagra A. Editorial: Genetic and Epigenetic Control of Immune Responses. Front Immunol. 2021 Oct 5;12:775101. doi: 10.3389/fimmu.2021.775101. PMID: 34675944.
McDonald JI, Diab N, Arthofer E, Hadley M, Kanholm T, Rentia U, Gomez S, Yu A, Grundy EE, Cox O, Topper MJ, Xing X, Strissel PL, Strick R, Wang T, Baylin SB, Chiappinelli KB. Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner. Cancer Res. 2021 Oct 15;81(20):5176-5189. doi: 10.1158/0008-5472.CAN-20-4243.
Steiner MC, Marston JL, Iñiguez LP, Bendall ML, Chiappinelli KB, Nixon DF, Crandall KA. Locus-Specific Characterization of Human Endogenous Retrovirus Expression in Prostate, Breast, and Colon Cancers. Cancer Res. 2021 Jul 1;81(13):3449-3460. doi: 10.1158/0008-5472.CAN-20-3975. PMID: 33941616.
Grundy EE, Diab N, Chiappinelli KB. Transposable element regulation and expression in cancer. FEBS J. 2022 Mar;289(5):1160-1179. doi: 10.1111/febs.15722.
2020
Banik D, Noonepalle S, Hadley M, Palmer E, Gracia-Hernandez M, Zevallos-Delgado C, Manhas N, Simonyan H, Young CN, Popratiloff A, Chiappinelli KB, Fernandes R, Sotomayor EM, Villagra A. HDAC6 plays a non-canonical role in the regulation of anti-tumor immune responses, dissemination, and invasiveness of breast cancer. Cancer Res. 2020 Sep 1;80(17):3649-3662. doi: 10.1158/0008-5472.CAN-19-3738. PMID: 32605998.
Moufarrij S, Srivastava A, Gomez S, Hadley M, Palmer E, Austin PT, Chisholm S, Diab N, Roche K, Yu A, Li J, Zhu W, Lopez-Acevedo M, Villagra A, Chiappinelli KB. Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer. Sci Rep. 2020 Feb 26;10(1):3470. doi: 10.1038/s41598-020-60409-4. PMID: 32103105.
2019
Gomez S, Tabernacki T, Kobyra J, Roberts P, Chiappinelli KB. Combining epigenetic and immune therapy to overcome cancer resistance. Semin Cancer Biol. 2020;65:99-113. doi:10.1016/j.semcancer.2019.12.019. PMID: 31877341.
Pfannstiel C, Strissel PL, Chiappinelli KB, Sikic D, Wach S, Wirtz RM, Wullweber A, Taubert H, Breyer J, Otto W, Worst T, Burger M, Wullich B, Bolenz C, Fuhrich N, Geppert CI, Weyerer V, Stoehr R, Bertz S, Keck B, Erlmeier F, Erben P, Hartmann A, Strick R, Eckstein M; BRIDGE Consortium, Germany; BRIDGE Consortium, Germany; BRIDGE Consortium, Germany; BRIDGE Consortium, Germany. The Tumor Immune Microenvironment. The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes. Cancer Immunol Res. 2019;7(6):923-938. doi:10.1158/2326-6066.CIR-18-0758.
Moufarrij S, Dandapani M, Arthofer E, Gomez S, Srivastava A, Lopez-Acevedo M, Villagra A, Chiappinelli KB. Epigenetic therapy for ovarian cancer: promise and progress. Clin Epigenetics. 2019;11(1):7; doi:10.1186/s13148-018-0602-0. PMID: 30646939.
2017
Stone ML*, Chiappinelli KB*, Li H, Murphy LM, Travers ME, Topper MJ, Mathios D, Lim M, Shih IM, Wang TL, Hung CF, Bhargava V, Wiehagen KR, Cowley GS, Bachman KE, Strick R, Strissel PL, Baylin SB, Zahnow CA. Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden. Proc Natl Acad Sci USA. 2017 Dec 4. pii: 201712514. doi: 10.1073/pnas.1712514114. PMID: 29203668.
Topper MJ, Vaz M, Chiappinelli KB, DeStefano Shields CE, Niknafs N, Yen RC, Wenzel A, Hicks J, Ballew M, Stone M, Tran PT, Zahnow CA, Hellmann MD, Anagnostou V, Strissel PL, Strick R, Velculescu VE, Baylin SB. Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer. Cell. 2017; 171(6):1284-1300.e21. PMID: 29195073.
Siebenkäs C*, Chiappinelli KB*, Guzzetta AA, Sharma A, Jeschke J, Vatapalli R, Baylin SB, Ahuja N. Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells. PloS one. 2017; 12(6):e0179501. PMID: 28622390.
2016
Chiappinelli KB, Moss BL, Lenz DS, Tonge NA, Joyce A, Holt GE, Holt LE, Woolsey TA. Evaluation to Improve a High School Summer Science Outreach Program. J Microbiol Biol Educ. 2016 May 4;17(2):225-36. doi: 10.1128/jmbe.v17i2.1003. PMID: 27158303.
Chiappinelli KB, Zahnow CA, Ahuja N, Baylin SB. Combining Epigenetic and Immunotherapy to Combat Cancer. Cancer Res. 2016; 76(7):1683-9.
2015
Strick R, Strissel PL, Baylin SB, Chiappinelli KB. Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors. Oncoimmunology. 2015; 5(5):e1122160.
Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC Jr, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, Edmondson R, Fotopoulou C, Gabra H, Galon J, Gourley C, Heong V, Huntsman DG, Iwanicki M, Karlan BY, Kaye A, Lengyel E, Levine DA, Lu KH, McNeish IA, Menon U, Narod SA, Nelson BH, Nephew KP, Pharoah P, Powell DJ Jr, Ramos P, Romero IL, Scott CL, Sood AK, Stronach EA, Balkwill FR. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nature Rev Cancer. 2015; 15(11):668-79.
Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Slamon DJ, Wolchok JD, Pardoll DM, Beckmann MW, Zahnow CA, Merghoub T, Chan TA, Baylin SB, Strick R. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 2015 Aug 27;162(5):974-86. doi: 10.1016/j.cell.2015.07.011. PMID: 26317466.
2014
Zhang B, Xing X, Li J, Lowdon RF, Zhou Y, Lin N, Zhang B, Sundaram V, Chiappinelli KB, Hagemann IS, Mutch DG, Goodfellow PJ, Wang T. Comparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers. BMC Genomics. 2014 Oct 6;15(1):868. doi: 10.1186/1471-2164-15-868. PMID: 25286960.
Li H*, Chiappinelli KB*, Guzzetta AA*, Easwaran H, Yen RW, Vatapalli R, Topper MJ, Luo J, Connolly RM, Azad NS, Stearns V, Pardoll DM, Davidson N, Jones PA, Slamon DJ, Baylin SB, Zahnow CA, Ahuja N. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget. 2014 Feb 15;5(3):587-98. doi: 10.18632/oncotarget.1782. PMID: 24583822.
2013
Yi JM, Guzzetta AA, Bailey VJ, Downing SR, Van Neste L, Chiappinelli KB, Keeley BP, Stark A, Herrera A, Wolfgang C, Pappou EP, Iacobuzio-Donahue CA, Goggins MG, Herman JG, Wang TH, Baylin SB, Ahuja N. Novel methylation biomarker panel for the early detection of pancreatic cancer. Clin Cancer Res. 2013 Dec 1;19(23):6544-6555. doi: 10.1158/1078-0432.CCR-12-3224. PMID: 24088737.
Yin Y, Kizer NT, Thaker PH, Chiappinelli KB, Trinkaus KM, Goodfellow PJ, Ma L. Glycogen synthase kinase 3β inhibition as a therapeutic approach in the treatment of endometrial cancer. Int J Mol Sci. 2013 Aug 12;14(8):16617-37. doi: 10.3390/ijms140816617. PMID: 23941783.
2012
Chiappinelli KB, Haynes BC, Brent MR, Goodfellow PJ. Reduced DICER1 elicits an interferon response in endometrial cancer cells.
Mol Cancer Res. 2012 Mar;10(3):316-25. doi: 10.1158/1541-7786.MCR-11-0520. PMID: 22252463.
Ioffe YJ, Chiappinelli KB, Mutch DG, Zighelboim I, Goodfellow PJ. Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis? Gynecol Oncol. 2012 Feb;124(2):340-6. doi: 10.1016/j.ygyno.2011.10.011. PMID: 22005521.
2010
Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang LW, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, Link DC. Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood. 2010 Dec 9;116(24):5316-26. doi: 10.1182/blood-2010-05-285395. PMID: 20876853.
Chiappinelli KB, Rimel BJ, Massad LS, Goodfellow PJ. Infrequent methylation of the DUSP6 phosphatase in endometrial cancer.
Gynecol Oncol. 2010 Oct;119(1):146-50. doi: 10.1016/j.ygyno.2010.06.015. PMID: 20638106.
Saharia A, Teasley DC, Duxin JP, Dao B, Chiappinelli KB, Stewart SA. FEN1 ensures telomere stability by facilitating replication fork re-initiation. J Biol Chem. 2010 Aug 27;285(35):27057-27066. doi: 10.1074/jbc.M110.112276. PMID: 20551483.